PT  - JOURNAL ARTICLE
AU  - Wei Deng
AU  - Linlin Bao
AU  - Hong Gao
AU  - Zhiguang Xiang
AU  - Yajin Qu
AU  - Zhiqi Song
AU  - Shunran Gong
AU  - Jiayi Liu
AU  - Jiangning Liu
AU  - Pin Yu
AU  - Feifei Qi
AU  - Yanfeng Xu
AU  - Fengli Li
AU  - Chong Xiao
AU  - Qi Lv
AU  - Jing Xue
AU  - Qiang Wei
AU  - Mingya Liu
AU  - Guanpeng Wang
AU  - Shunyi Wang
AU  - Haisheng Yu
AU  - Xing Liu
AU  - Wenjie Zhao
AU  - Yunlin Han
AU  - Chuan Qin
TI  - Rhesus macaques can be effectively infected with SARS-CoV-2 via ocular conjunctival route
AID  - 10.1101/2020.03.13.990036
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.03.13.990036
4099  - http://biorxiv.org/content/early/2020/03/14/2020.03.13.990036.short
4100  - http://biorxiv.org/content/early/2020/03/14/2020.03.13.990036.full
AB  - The outbreak of Corona Virus Disease 2019 (COVID-19) is highly infectious and transmitted mainly through human-to-human transmission via respiratory droplets and direct or close contact to the patients with SARS-CoV-2. The other potential transmission routes remain to be further researched. In some clinical cases, samples of tears and conjunctival secretions from both SARS-CoV[1] and SARS-CoV-2 patients with conjunctivitis[2] displayed detectable viral RNA. A previous study reported the case of a clinician who was infected with SARS-CoV-2 while working with patients under all safeguards except eye protection [2]. By contrast, no SARS-CoV-2 could be detected by RT-PCR in 114 conjunctival swabs samples from patients with COVID-19 pneumonia [4]. Anatomically, the linkage of the ocular with respiratory tissues is primarily by the nasolacrimal system [5]. The potential extra-respiratory transmissible routes of SARS-CoV-2 via ocular remained unclear. Whether ocular conjunctiva is one of the portals that SARS-CoV-2 enters the host needs to be further research by laboratory-confirmation for providing significant data to oversight and prevention in people.