PT  - JOURNAL ARTICLE
AU  - Myung-Shin Kim
AU  - Roberto Lozano
AU  - Ji Hong Kim
AU  - Dong Nyuk Bae
AU  - Sang-Tae Kim
AU  - Jung-Ho Park
AU  - Man Soo Choi
AU  - Jaehyun Kim
AU  - Hyun Choong Ok
AU  - Soo-Kwon Park
AU  - Michael A. Gore
AU  - Jung-Kyung Moon
AU  - Soon-Chun Jeong
TI  - Purging of deleterious mutations during domestication in the predominant selfing crop soybean
AID  - 10.1101/2020.03.12.989830
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.03.12.989830
4099  - http://biorxiv.org/content/early/2020/03/14/2020.03.12.989830.short
4100  - http://biorxiv.org/content/early/2020/03/14/2020.03.12.989830.full
AB  - As a predominant plant protein and oil source for both food and feed, soybean is unique in that both domesticated and wild types are predominantly selfing. Here we present a genome-wide variation map of 781 soybean accessions that include 418 domesticated (Glycine max) and 345 wild (Glycine soja) accessions and 18 of their natural hybrids. We identified 10.5 million single nucleotide polymorphisms and 5.7 million small indels that contribute to within- and between-population variations. We describe improved detection of domestication-selective sweeps and drastic reduction of overall deleterious alleles in domesticated soybean relative to wild soybean in contrast to the cost of domestication hypothesis. This resource enables the marker density of existing data sets to be increased to improve the resolution of association studies.