RT Journal Article
SR Electronic
T1 Oscillatory brain states govern spontaneous fMRI network dynamics
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 393389
DO 10.1101/393389
A1 Daniel Gutierrez-Barragan
A1 M. Albert Basson
A1 Stefano Panzeri
A1 Alessandro Gozzi
YR 2018
UL http://biorxiv.org/content/early/2018/08/20/393389.abstract
AB Spontaneous brain activity as assessed with resting-state fMRI exhibits rich spatiotemporal structure. However, the principles by which brain-wide patterns of spontaneous fMRI activity reconfigure and interact with each other, remain unclear. We devised a frame-wise clustering approach to map spatiotemporal dynamics of spontaneous fMRI activity with voxel resolution in the resting mouse brain. We show that brain-wide patterns of fMRI co-activation can be reliably mapped at the group and subject level, defining a restricted set of recurring brain states characterized by rich network structure. We document that these functional states are characterized by contrasting patterns of spontaneous fMRI activity and exhibit coupled oscillatory dynamics, with each state occurring at specific phases of global fMRI signal fluctuations. Finally, we show that autism-associated genetic alterations result in the engagement of non-canonical brain states and altered coupled oscillatory dynamics. Our approach reveals a new set of fundamental principles guiding the spatiotemporal organization of resting state fMRI activity, and its disruption in brain disorders.