PT  - JOURNAL ARTICLE
AU  - Yang Hai
AU  - Nan Chen
AU  - Wenwen Wu
AU  - Zihuai Wang
AU  - Feng Lin
AU  - Chenglin Guo
AU  - Chengwu Liu
AU  - Weiming Li
AU  - Lunxu Liu
TI  - High Postoperative Monocyte Indicated Inferior Clinicopathological Characteristics and Worse Prognosis in Lung Adenocarcinoma or Squamous Cell Carcinoma after Lobectomy
AID  - 10.1101/395632
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 395632
4099  - http://biorxiv.org/content/early/2018/08/20/395632.1.short
4100  - http://biorxiv.org/content/early/2018/08/20/395632.1.full
AB  - Background Peripheral monocyte count is an assessable parameter. Recently, evidence suggested an elevated preoperative monocyte counts predicting poor prognosis in malignancies. The aim of this study was to determine the prognostic effect of early postoperative blood monocyte count in patients with lung adenocarcinoma or squamous cell carcinoma following lobectomy.Methods We retrospectively reviewed patients with operated lung adenocarcinoma or squamous cell carcinoma from 2006 to 2011 in Western China Lung Cancer database. Univariate analysis on disease-free survival (DFS) and overall survival (OS) was performed using the Kaplan-Meier and log-rank tests, and multivariate analysis was conducted using the Cox proportional hazards regression model.Results There were 433 patients enrolled in our analysis. High postoperative elevated monocyte was associated with male gender (P<0.001), positive smoking history (P=0.005), and higher N stage (P=0.002) and higher tumor stage (P=0.026). Two-tailed log-rank test indicated patients with an early postoperative elevated monocyte count predicted a poor DFS and OS overall (P<0.001, P<0.001, respectively) as well as in subgroup analysis, and further presented as a promising independent prognostic factor for both DFS and OS (HR=2.991, 95%CI: 2.243-3.988, P<0.001; HR=2.705, 95%CI: 1.977-3.700, P<0.001, respectively) on multivariate analysis. However, no significance was detected for preoperative monocyte in multivariate analysis.Conclusions Elevated early postoperative peripheral monocyte count was an independent prognostic factor of poor prognosis and inferior clinicopathological features for patients with operable lung adenocarcinoma or squamous cell carcinoma by lobectomy.OSoverall survivalDFSdisease-free survivalNSCLCnon-small cell lung cancerTNFtissue necrosis factorILinterleukinMRImagnetic resonance imagingPET-CTpositron emission tomography scan and CTROCreceiver operating characteristicVATSvideo-assisted thoracic surgeryAUCarea under the curveAPCsantigen-presenting cellsTAMstumor-associated macrophages