TY - JOUR T1 - A Novel Small Animal Model of Norovirus Diarrhea JF - bioRxiv DO - 10.1101/2020.03.19.999185 SP - 2020.03.19.999185 AU - Alexa N. Roth AU - Emily W. Helm AU - Carmen Mirabelli AU - Erin Kirsche AU - Jonathan C. Smith AU - Laura B. Eurell AU - Sourish Ghosh AU - Nihal Altan-Bonnet AU - Christiane E. Wobus AU - Stephanie M. Karst Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/03/20/2020.03.19.999185.abstract N2 - Human noroviruses are the leading cause of severe childhood diarrhea worldwide yet we know very little about their pathogenic mechanisms. Murine noroviruses cause diarrhea in interferon-deficient adult mice but these hosts also develop systemic pathology and lethality, reducing confidence in the translatability of findings to human norovirus disease. Herein we report that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice, thus mirroring the key features of human norovirus disease and representing a robust norovirus small animal disease model. Intriguingly, lymphocytes are critical for controlling acute norovirus replication while simultaneously contributing to disease severity, likely reflecting their dual role as targets of viral infection and key components of the host response. ER -