TY - JOUR T1 - Exploring the genetic correlations of antisocial behavior and life history traits JF - bioRxiv DO - 10.1101/247411 SP - 247411 AU - Jorim J. Tielbeek AU - J.C. Barnes AU - Arne Popma AU - Tinca J.C. Polderman AU - James J. Lee AU - John R.B. Perry AU - Danielle Posthuma AU - Brian B. Boutwell Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/08/23/247411.abstract N2 - Prior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviors in human and non-human species. Behavioral genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations may share genetic etiologies. We use GWAS data to estimate the genetic correlations between various measures of reproductive development (N= 52,776 – 318,863) and antisocial behavior (N= 31,968). Our genetic correlation analyses demonstrate that alleles associated with higher reproductive output (number of children ever born, rg=0.50, p=.0065) were positively correlated with alleles associated with antisocial behavior, whereas alleles associated with more delayed reproductive onset (age of first birth, rg=-.64, p=.0008) were negatively associated with alleles linked to antisocial behavior. Ultimately, these findings coalesce with evolutionary theories suggesting that increased antisocial behaviors may partly represent a faster life history approach, which may be significantly calibrated by genes. ER -