TY - JOUR T1 - The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2 JF - bioRxiv DO - 10.1101/2020.02.08.939553 SP - 2020.02.08.939553 AU - James Zhu AU - Jiwoong Kim AU - Xue Xiao AU - Yunguan Wang AU - Danni Luo AU - Ran Chen AU - Lin Xu AU - He Zhang AU - Guanghua Xiao AU - John W. Schoggins AU - Xiaowei Zhan AU - Tao Wang AU - Yang Xie Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/03/23/2020.02.08.939553.abstract N2 - The outbreak of the 2019 Novel Coronavirus (SARS-CoV-2) rapidly spread from Wuhan, China to more than 150 countries, areas or territories, causing staggering number of infections and deaths. A systematic profiling of the immune vulnerability landscape of SARS-CoV-2, which can bring critical insights into the immune clearance mechanism, peptide vaccine development, and antiviral antibody development, is lacking. In this study, we investigated the potential of the SARS-CoV-2 viral proteins to induce class I and II MHC presentation and to form linear antibody epitopes. We created an online database to broadly share the predictions as a resource for the research community. Using this resource, we showed that genetic variations in SARS- CoV-2, though still few for the moment, already follow the pattern of mutations in related coronaviruses, and could alter the immune vulnerability landscape of this virus. Importantly, we discovered evidence that SARS-CoV-2, along with related coronaviruses, used mutations to evade attack from the human immune system. Overall, we present an immunological resource for SARS-CoV-2 that could promote both therapeutic development and mechanistic research. ER -