RT Journal Article
SR Electronic
T1 PIRD: Pan immune repertoire database
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 399493
DO 10.1101/399493
A1 Wei Zhang
A1 Longlong Wang
A1 Ke Liu
A1 Xiaofeng Wei
A1 Kai Yang
A1 Wensi Du
A1 Shiyu Wang
A1 Nannan Guo
A1 Chuanchuan Ma
A1 Lihua Luo
A1 Jinghua Wu
A1 Liya Lin
A1 Fan Yang
A1 Fei Gao
A1 Xie Wang
A1 Tao Li
A1 Ruifang Zhang
A1 Nitin K. Saksena
A1 Huanming Yang
A1 Jian Wang
A1 Lin Fang
A1 Yong Hou
A1 Xun Xu
A1 Xiao Liu
YR 2018
UL http://biorxiv.org/content/early/2018/08/25/399493.abstract
AB The adaptive immunity is highly specific and mainly comprised of humoral immunity, mediated by antibodies produced by B lymphocytes, and cell-mediated immunity, mediated by T lymphocytes. The huge variety of T and B cell receptor (TCR and BCR) repertoire is vital in directly binding to various auto-and-external antigens. This repertoire is a critical resource for a clear understanding of the immune response and highlights its utility in clinical applications. In recent years, even thousands of samples have been captured for studying TCR and BCR repertoire using sequencing platforms, very few databases have been constructed to store these sequences. To resolve this issue, we have developed a database Pan immune repertoire database (PIRD), located the infrastructure of in China National GeneBank (CNGB) to collect and store the annotated TCR and BCR sequencing data, including Homo sapiens and other species. Except for the primary data storage, PIRD also provides the data visualization function in addition to the interactive online analysis. Additionally, a manually curated database of T- and B-cell receptors targeting known antigens (TBAdb) are also deposited in PIRD. The database is displayed in both English and Chinese on the PIRD website. PIRD can be accessed at https://db.cngb.org/