RT Journal Article
SR Electronic
T1 Top-down coordination of local cortical state during selective attention
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.03.26.009365
DO 10.1101/2020.03.26.009365
A1 van Kempen, Jochem
A1 Gieselmann, Marc A.
A1 Boyd, Michael
A1 Steinmetz, Nicholas A.
A1 Moore, Tirin
A1 Engel, Tatiana A.
A1 Thiele, Alexander
YR 2020
UL http://biorxiv.org/content/early/2020/03/26/2020.03.26.009365.abstract
AB Spontaneous fluctuations in cortical excitability influence sensory processing and behavior. These fluctuations, long known to reflect global changes in cortical state, were recently found to be modulated locally within a retinotopic map during spatially selective attention. We found that periods of vigorous (On) and faint (Off) spiking activity, the signature of cortical state fluctuations, were coordinated across brain areas along the visual hierarchy and tightly coupled to their retinotopic alignment. During top-down attention, this interareal coordination was enhanced and progressed along the reverse cortical hierarchy. The extent of local state coordination between areas was predictive of behavioral performance. Our results show that cortical state dynamics are shared across brain regions, modulated by cognitive demands and relevant for behavior.One Sentence Summary Interareal coordination of local cortical state is retinotopically precise and progresses in a reverse hierarchical manner during selective attention.