TY - JOUR T1 - Effects of episodic future thinking on temporal discounting: a re-analysis of six data sets using hierarchical Bayesian parameter estimation and compilation of effect sizes JF - bioRxiv DO - 10.1101/2020.03.24.005892 SP - 2020.03.24.005892 AU - Jan Peters AU - Stefanie Brassen AU - Uli Bromberg AU - Christian Büchel AU - Laura Sasse AU - Antonius Wiehler Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/03/26/2020.03.24.005892.abstract N2 - Temporal discounting refers to the tendency of humans and many animals to devalue rewards as a function of time. Steep discounting of value over time is associated with a range of psychiatric disorders, including substance use disorders and behavioral addictions, and therefore of potentially high clinical relevance. One cognitive factor that has repeatedly been shown to reduce temporal discounting in humans is episodic future thinking, the process of vividly imagining future outcomes, which has been linked to hippocampal mechanisms in a number of studies. However, the analytical approaches used to quantify the behavioral effects have varied between studies, which complicates a direct comparison of the obtained effect sizes. Here we re-analyzed temporal discounting data from previously published functional magnetic resonance imaging (fMRI) and behavioral studies (six data sets from five papers, n=204 participants in total) using an identical model structure and hierarchical Bayesian parameter estimation procedure. Analyses confirmed that engagement in episodic future thinking leads to robust and and consistent reductions in temporal discounting with on average medium effect sizes. In contrast, effects on choice consistency (decision noise) where small and with inconsistent directionality. We provide standardized and unstandardized effect size estimates for each data set and discuss clinical implications as well as issues of hierarchical Bayesian parameter estimation. ER -