RT Journal Article
SR Electronic
T1 The Probability of Fusions Joining Sex Chromosomes and Autosomes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.03.28.010751
DO 10.1101/2020.03.28.010751
A1 Nathan W. Anderson
A1 Heath Blackmon
YR 2020
UL http://biorxiv.org/content/early/2020/03/29/2020.03.28.010751.abstract
AB Chromosome fusion and fission are primary mechanisms of karyotype evolution. In particular, the fusion of a sex chromosome and an autosome has been proposed as a mechanism to resolve intralocus sexual antagonism. If sexual antagonism is common throughout the genome, we should expect to see an excess of fusions that join sex chromosomes and autosomes. Here, we present a null model that provides the probability of a sex chromosome autosome fusion, assuming all chromosomes have an equal probability of being involved in a fusion. This closed-form expression is applicable to both male and female heterogametic sex chromosome systems and can accommodate unequal proportions of fusions originating in males and females.