TY - JOUR T1 - The Probability of Fusions Joining Sex Chromosomes and Autosomes JF - bioRxiv DO - 10.1101/2020.03.28.010751 SP - 2020.03.28.010751 AU - Nathan W. Anderson AU - Heath Blackmon Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/03/29/2020.03.28.010751.abstract N2 - Chromosome fusion and fission are primary mechanisms of karyotype evolution. In particular, the fusion of a sex chromosome and an autosome has been proposed as a mechanism to resolve intralocus sexual antagonism. If sexual antagonism is common throughout the genome, we should expect to see an excess of fusions that join sex chromosomes and autosomes. Here, we present a null model that provides the probability of a sex chromosome autosome fusion, assuming all chromosomes have an equal probability of being involved in a fusion. This closed-form expression is applicable to both male and female heterogametic sex chromosome systems and can accommodate unequal proportions of fusions originating in males and females. ER -