RT Journal Article
SR Electronic
T1 Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.03.30.015461
DO 10.1101/2020.03.30.015461
A1 Chek Meng Poh
A1 Guillaume Carissimo
A1 Bei Wang
A1 Siti Naqiah Amrun
A1 Cheryl Yi-Pin Lee
A1 Rhonda Sin-Ling Chee
A1 Nicholas Kim-Wah Yeo
A1 Wen-Hsin Lee
A1 Yee-Sin Leo
A1 Mark I-Cheng Chen
A1 Seow-Yen Tan
A1 Louis Yi Ann Chai
A1 Shirin Kalimuddin
A1 Siew-Yee Thien
A1 Barnaby Edward Young
A1 David C. Lye
A1 Cheng-I Wang
A1 Laurent Renia
A1 Lisa F.P. Ng
YR 2020
UL http://biorxiv.org/content/early/2020/03/31/2020.03.30.015461.abstract
AB The ongoing SARS-CoV-2 pandemic demands rapid identification of immunogenic targets for the design of efficient vaccines and serological detection tools. In this report, using pools of overlapping linear peptides and functional assays, we present two immunodominant regions on the spike glycoprotein that were highly recognized by neutralizing antibodies in the sera of COVID-19 convalescent patients. One is highly specific to SARS-CoV-2, and the other is a potential pan-coronavirus target.