PT  - JOURNAL ARTICLE
AU  - Antonio C. Pagano Zottola
AU  - Edgar Soria-Gomez
AU  - Itziar Bonilla-del-Río
AU  - Carolina Muguruza
AU  - Geoffrey Terral
AU  - Laurie M. Robin
AU  - José F. Oliveira da Cruz
AU  - Bastien Redon
AU  - Thierry Lesté-Lasserre
AU  - Tarson Tolentino-Cortes
AU  - Nagore Puente
AU  - Gabriel Barreda-Gómez
AU  - Francis Chaouloff
AU  - Luis F. Callado
AU  - Pedro Grandes
AU  - Giovanni Marsicano
AU  - Luigi Bellocchio
TI  - A new mutant mouse model lacking mitochondrial-associated CB<sub>1</sub> receptor
AID  - 10.1101/2020.03.30.009472
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.03.30.009472
4099  - http://biorxiv.org/content/early/2020/03/31/2020.03.30.009472.short
4100  - http://biorxiv.org/content/early/2020/03/31/2020.03.30.009472.full
AB  - The idea that the effects of drugs largely depend on subcellular target location is emerging as a novel predictive factor of their beneficial or adverse outcomes. G protein-coupled type-1 cannabinoid receptors (CB1) are regulators of several brain functions as well as the main targets of cannabinoid-based medicines.Besides their classical location at plasma membranes, CB1 receptors are present at different locations within cells, including in association to mitochondrial membranes (mtCB1). Here we report the generation and characterization of a mutant mouse line, which lack mtCB1 receptors.