RT Journal Article
SR Electronic
T1 Visual experience regulates the intrinsic excitability of visual cortical neurons to maintain sensory function
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 402768
DO 10.1101/402768
A1 Alexander P.Y. Brown
A1 Lee Cossell
A1 Troy W. Margrie
YR 2018
UL http://biorxiv.org/content/early/2018/08/29/402768.abstract
AB This in vivo study shows that both intrinsic and sensory-evoked synaptic properties of layer 2/3 neurons in mouse visual cortex are modified by ongoing visual input. Following visual deprivation, intrinsic properties are significantly altered, although orientation selectivity across the population remains unchanged. We therefore suggest that cortical cells adjust their intrinsic excitability in an activity-dependent manner to compensate for changes in synaptic drive and maintain sensory network function.