RT Journal Article
SR Electronic
T1 Direct RNA sequencing and early evolution of SARS-CoV-2
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.03.05.976167
DO 10.1101/2020.03.05.976167
A1 Taiaroa, George
A1 Rawlinson, Daniel
A1 Featherstone, Leo
A1 Pitt, Miranda
A1 Caly, Leon
A1 Druce, Julian
A1 Purcell, Damian
A1 Harty, Leigh
A1 Tran, Thomas
A1 Roberts, Jason
A1 Scott, Nichollas
A1 Catton, Mike
A1 Williamson, Deborah
A1 Coin, Lachlan
A1 Duchene, Sebastian
YR 2020
UL http://biorxiv.org/content/early/2020/04/03/2020.03.05.976167.abstract
AB Fundamental aspects of SARS-CoV-2 biology remain to be described, having the potential to provide insight to the response effort for this high-priority pathogen. Here we describe the first native RNA sequence of SARS-CoV-2, detailing the coronaviral transcriptome and epitranscriptome, and share these data publicly. A data-driven inference of viral genetic features and evolutionary rate is also made. The rapid sharing of sequence information throughout the SARS-CoV-2 pandemic represents an inflection point for public health and genomic epidemiology, providing early insights into the biology and evolution of this emerging pathogen.