PT  - JOURNAL ARTICLE
AU  - Francesca Rocchi
AU  - Hiroyuki Oya
AU  - Fabien Balezeau
AU  - Alexander J. Billig
AU  - Zsuzsanna Kocsis
AU  - Rick Jenison
AU  - Kirill V. Nourski
AU  - Christopher K. Kovach
AU  - Mitchell Steinschneider
AU  - Yukiko Kikuchi
AU  - Ariane E. Rhone
AU  - Brian J. Dlouhy
AU  - Hiroto Kawasaki
AU  - Ralph Adolphs
AU  - Jeremy D.W. Greenlee
AU  - Timothy D. Griffiths
AU  - Matthew A. Howard
AU  - Christopher I. Petkov
TI  - Common Fronto-temporal Effective Connectivity in Humans and Monkeys
AID  - 10.1101/2020.04.03.024042
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.04.03.024042
4099  - http://biorxiv.org/content/early/2020/04/05/2020.04.03.024042.short
4100  - http://biorxiv.org/content/early/2020/04/05/2020.04.03.024042.full
AB  - Cognitive pathways supporting human language and declarative memory are thought to have uniquely evolutionarily differentiated in our species. However, cross-species comparisons are missing on site-specific effective connectivity between regions important for cognition. We harnessed a new approach using functional imaging to visualize the impact of direct electrical brain stimulation in human neurosurgery patients. Applying the same approach with macaque monkeys, we found remarkably comparable patterns of effective connectivity between auditory cortex and ventro-lateral prefrontal cortex (vlPFC) and parahippocampal cortex in both species. Moreover, in humans electrical tractography revealed rapid evoked potentials in vlPFC from stimulating auditory cortex and speech sounds drove vlPFC, consistent with prior evidence in monkeys of direct projections from auditory cortex to vocalization responsive regions in vlPFC. The results identify a common effective connectivity signature that from auditory cortex is equally direct to vlPFC and indirect to the hippocampus (via parahippocampal cortex) in human and nonhuman primates.HighlightsPrivileged human auditory to inferior frontal connectivity, linked to monkeysCommon auditory to parahippocampal effective connectivity in both speciesGreater lateralization in human effective connectivity, more symmetrical in monkeysHuman fronto-temporal network function rooted in evolutionarily conserved signatureeTOC short summary Functional connectivity between regions crucial for language and declarative memory is thought to have substantially differentiated in humans. Using a new technique to similarly visualize directional effective connectivity in humans and monkeys, we found remarkably comparable connectivity patterns in both species between fronto-temporal regions crucial for cognition.