RT Journal Article
SR Electronic
T1 Natural gene drives offer potential pathogen control strategies in plants
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.04.05.026500
DO 10.1101/2020.04.05.026500
A1 Gardiner, Donald M.
A1 Rusu, Anca
A1 Barrett, Luke
A1 Hunter, Gavin C.
A1 Kazan, Kemal
YR 2020
UL http://biorxiv.org/content/early/2020/04/06/2020.04.05.026500.abstract
AB Globally, fungal pathogens cause enormous crop losses and current control practices are not always effective, economical or environmentally sustainable. Tools enabling genetic management of wild pathogen populations could potentially solve many problems associated with plant diseases.A natural gene drive from a heterologous species can be used in the globally important cereal pathogen, Fusarium graminearum, to remove pathogenic traits from contained populations of the fungus. The gene drive element became fixed in a freely crossing populations in only three generations.Repeat induce point mutation, a natural genome defence mechanism in fungi, may be useful to recall the gene drive following release, should a failsafe mechanism be required.We propose that gene drive technology is a potential tool to control plant pathogens.