RT Journal Article
SR Electronic
T1 Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.01.26.919985
DO 10.1101/2020.01.26.919985
A1 Yu Zhao
A1 Zixian Zhao
A1 Yujia Wang
A1 Yueqing Zhou
A1 Yu Ma
A1 Wei Zuo
YR 2020
UL http://biorxiv.org/content/early/2020/04/09/2020.01.26.919985.abstract
AB A novel coronavirus SARS-CoV-2 was identified in Wuhan, Hubei Province, China in December of 2019. According to WHO report, this new coronavirus has resulted in 76,392 confirmed infections and 2,348 deaths in China by 22 February, 2020, with additional patients being identified in a rapidly growing number internationally. SARS-CoV-2 was reported to share the same receptor, Angiotensin-converting enzyme 2 (ACE2), with SARS-CoV. Here based on the public database and the state-of-the-art single-cell RNA-Seq technique, we analyzed the ACE2 RNA expression profile in the normal human lungs. The result indicates that the ACE2 virus receptor expression is concentrated in a small population of type II alveolar cells (AT2). Surprisingly, we found that this population of ACE2-expressing AT2 also highly expressed many other genes that positively regulating viral entry, reproduction and transmission. This study provides a biological background for the epidemic investigation of the COVID-19, and could be informative for future anti-ACE2 therapeutic strategy development.Competing Interest StatementThe authors have declared no competing interest.