RT Journal Article
SR Electronic
T1 Environmental enrichment alleviates the deleterious effects of stress in experimental autoimmune encephalomyelitis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.04.10.033662
DO 10.1101/2020.04.10.033662
A1 Antoine Philippe Fournier
A1 Erwan Baudron
A1 Isabelle Wagnon
A1 Philippe Aubert
A1 Denis Vivien
A1 Michel Neunlist
A1 Isabelle Bardou
A1 Fabian Docagne
YR 2020
UL http://biorxiv.org/content/early/2020/04/11/2020.04.10.033662.abstract
AB Clinical observations support the hypothesis that stressful events increase relapse occurrence in multiple sclerosis patients, while stress-reduction strategies can modulate this effect. However, a direct cause-effect relationship between stress level and relapse cannot be firmly established from these data. The purpose of this work was to address whether modulation of stress could interfere with symptom relapse in an animal model of multiple sclerosis with relapsing-remitting course. We report that repeated acute stress induced a twofold increase in relapse incidence in experimental autoimmune encephalomyelitis. On the other hand, environmental enrichment reduced relapse incidence and severity, and reversed the effects of repeated acute stress. These data provide the platform for further studies on the biological processes that link stress and multiple sclerosis relapses in a suitable animal model.Competing Interest StatementThe authors have declared no competing interest.MSMultiple sclerosisEAEExperimental autoimmune encephalomyelitisRR-EAERelapsing-Remitting EAEPLPProteolipid proteinCFAComplete Freund adjuvantWASWater avoidance stressEEEnriched EnvironmentSTDStandard Environment