TY - JOUR T1 - Cell-Type-Specific Expression of Renin-Angiotensin-System Components in the Human Body and Its Relevance to SARS-CoV-2 Infection JF - bioRxiv DO - 10.1101/2020.04.11.034603 SP - 2020.04.11.034603 AU - Hemant Suryawanshi AU - Pavel Morozov AU - Thangamani Muthukumar AU - Benjamin R. tenOever AU - Masashi Yamaji AU - Zev Williams AU - Thomas Tuschl Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/04/11/2020.04.11.034603.abstract N2 - We have analyzed the cell-type-specific expression of the renin-angiotensin system (RAS) components across 141 cell types or subtypes as defined by single-cell RNA-seq (scRNA-seq) analysis. ACE2, one of the components of RAS, also facilitates SARS-CoV-2 entry into cells in cooperation with its associated protease TMPRSS2. Therefore, our analysis also contributes to the understanding of SARS-CoV-2 infection, spreading of the virus throughout the body, and potential viral interference with RAS in COVID-19 patients.Competing Interest StatementThe authors have declared no competing interest. ER -