PT - JOURNAL ARTICLE AU - Tomasz J Nowakowski AU - Neha Rani AU - Mahdi Golkaram AU - Hongjun R Zhou AU - Beatriz Alvarado AU - Kylie Huch AU - Jay A West AU - Anne Leyrat AU - Alex A Pollen AU - Arnold R Kriegstein AU - Linda R Petzold AU - Kenneth S. Kosik TI - Regulation of Cell-Type-Specific Transcriptomes by miRNA Networks During Human Brain Development AID - 10.1101/412510 DP - 2018 Jan 01 TA - bioRxiv PG - 412510 4099 - http://biorxiv.org/content/early/2018/09/09/412510.short 4100 - http://biorxiv.org/content/early/2018/09/09/412510.full AB - MicroRNAs (miRNAs) regulate many cellular events by regulating hundreds of mRNA transcripts. However, it is unclear how miRNA-mRNA interactions are contextualized into the framework of transcriptional heterogeneity among closely related cells of the developing human brain. By combining the multiple complementary approaches, AGO2-HITS-CLIP, single-cell profiling and bipartite network analysis, we show that the miRNA-mRNA network operates as functional modules related to cell-type identities and undergo dynamic transitions during brain development.