TY - JOUR T1 - Regulation of Cell-Type-Specific Transcriptomes by miRNA Networks During Human Brain Development JF - bioRxiv DO - 10.1101/412510 SP - 412510 AU - Tomasz J Nowakowski AU - Neha Rani AU - Mahdi Golkaram AU - Hongjun R Zhou AU - Beatriz Alvarado AU - Kylie Huch AU - Jay A West AU - Anne Leyrat AU - Alex A Pollen AU - Arnold R Kriegstein AU - Linda R Petzold AU - Kenneth S. Kosik Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/09/09/412510.abstract N2 - MicroRNAs (miRNAs) regulate many cellular events by regulating hundreds of mRNA transcripts. However, it is unclear how miRNA-mRNA interactions are contextualized into the framework of transcriptional heterogeneity among closely related cells of the developing human brain. By combining the multiple complementary approaches, AGO2-HITS-CLIP, single-cell profiling and bipartite network analysis, we show that the miRNA-mRNA network operates as functional modules related to cell-type identities and undergo dynamic transitions during brain development. ER -