RT Journal Article
SR Electronic
T1 Filovirus infection induces an anti-inflammatory state in Rousettus bats
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.04.13.039503
DO 10.1101/2020.04.13.039503
A1 Anitha D. Jayaprakash
A1 Adam J. Ronk
A1 Abhishek N. Prasad
A1 Michael F. Covington
A1 Kathryn R. Stein
A1 Toni M. Schwarz
A1 Saboor Hekmaty
A1 Karla A. Fenton
A1 Thomas W Geisbert
A1 Christopher F. Basler
A1 Alexander Bukreyev
A1 Ravi Sachidanandam
YR 2020
UL http://biorxiv.org/content/early/2020/04/15/2020.04.13.039503.abstract
AB The filoviruses Ebola (EBOV) and Marburg (MARV) cause severe disease in humans. In contrast, the Egyptian rousette bat (Rousettus aegyptiacus), a natural reservoir of MARV, exhibits a subclinical phenotype with limited MARV replication and nearly undetectable EBOV replication. Rousettus cell lines support replication of filoviruses, however. To understand the bat-filovirus interaction, transcriptomes of tissues from EBOV- and MARV-infected R. aegyptiacus bats were analyzed. While viral transcripts were only detected in liver, a systemic response was observed involving other tissues as well. By focusing on evolutionarily divergent (from human homologues) protein-coding genes, we identified novel transcriptional pathways that suggest infected bats exhibit impaired coagulation, vasodilation, aberrant iron regulation, and impaired complement system leading to muted antibody responses. Furthermore, a robust T-cell response and an anti-inflammatory state driven by M2 macrophages were identified. These processes likely control infection and limit pathology. All data can be freely explored and downloaded through our tools (http://katahdin.girihlet.com/shiny/bat/).Competing Interest StatementThe authors have declared no competing interest.