TY - JOUR T1 - Descriptive analysis in time and space of recorded data for Buruli Ulcer occurrence in Victoria over 22 years JF - bioRxiv DO - 10.1101/413542 SP - 413542 AU - Michael S. Avumegah AU - Ee Laine Tay AU - Soren Alexandersen AU - Wojtek P. Michalski AU - Daniel P. O’Brien AU - Isabelle Jeanne AU - Eugene Athan Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/09/10/413542.abstract N2 - Background Buruli ulcer (BU) is a subcutaneous necrotic infection of the skin caused by Mycobacterium ulcerans. There has been increasing BU incidence in Victoria, Australia. The aim of this study to provide an epidemiological update of BU cases in Victoria to understand the pattern of distribution over time and space and attempt to identify local risk factors.Methods A comprehensive descriptive epidemiological analyses were performed on BU notification data from 1994 to 2016. In addition, retrospective temporal, spatial and spatio-temporal analyses were conducted to understand the distribution of cases. Quantum GIS was used to generate maps. Demographic, new housing settlements and historical rainfall data were analysed to assess their effects on BU incidence in Victoria.Findings There were a total of 902 patients notified from 1994-2016. The incidence rate was 0.8/100,000 persons in Victoria. Space and time analyses showed that the most likely disease cluster was the Bellarine and Mornington Peninsulas with incidence rate 50 times higher than the State of Victoria rate. Gender was not a risk factor, but age was, with increased susceptibility among the over 60 year old group. There was an unusual high risk in the 15-24 age group in Point Lonsdale. Correlation analyses indicated that increase in population and construction of new settlements might be some of the reasons contributing to the rise in cases in Victoria.Interpretation The findings agreed with published works in Australia of the increase in BU cases in Victoria. However, our findings also highlights the endemic nature of cases. The identified spatial disease clusters could be relevant for future environmental sampling studies or screening tests for M. ulcerans exposure.Author Summary Buruli ulcer (BU) has been reported in 33 countries, mainly from the Tropics and Sub-tropics. Tropical cases are mainly within the West African region. Australia is the only country outside Africa in the top six highest incidence countries for BU. The exact mode of transmission remains unclear. Disease cases are rising in Australia, especially in Victoria for reasons that remains unclear. We have provided a descriptive epidemiological analyses in space and time of 22 years of recorded data on BU cases in Victoria from 1994 to 2016. We have also discussed demographic and new settlement dynamics over the study period. There were a total of 902 PCR-confirmed BU cases from 245 suburbs. Five suburbs on the Bellarine and Mornington Peninsulas were identified as the most endemic locations in Victoria. Spatial analyses detected a wider disease cluster area on the Peninsulas. We propose environmental sampling for risk factors analyses should focus on the endemic regions and some secondary clusters. ER -