PT  - JOURNAL ARTICLE
AU  - Rui Borges
AU  - Gergely Szöllősi
AU  - Carolin Kosiol
TI  - Quantifying GC-biased gene conversion in great ape genomes using polymorphism-aware models
AID  - 10.1101/380246
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 380246
4099  - http://biorxiv.org/content/early/2018/09/10/380246.short
4100  - http://biorxiv.org/content/early/2018/09/10/380246.full
AB  - As multi-individual population-scale data is becoming available, more-complex modeling strategies are needed to quantify the genome-wide patterns of nucleotide usage and associated mechanisms of evolution. Recently, the multivariate neutral Moran model was proposed. However, it was shown insufficient to explain the distribution of alleles in great apes. Here, we propose a new model that includes allelic selection. Our theoretical results constitute the basis of a new Bayesian framework to estimate mutation rates and selection coefficients from population data. We employ the new framework to quantify the patterns of genome-wide GC-biased gene conversion (gBCG) in great apes. In particular, we show that great apes have patterns of allelic selection that vary in intensity, a feature that we correlated with the great apes’ distinct demographies. We also demonstrate that the AT/GC toggling effect decreases the probability of a substitution, which promotes more polymorphisms in the base composition of great ape genomes. We further assess the impact of CG-bias in molecular analysis and we find that mutation rates and genetic distances are estimated under bias when gBGC is not properly accounted. Our results contribute to the discussion on the tempo and mode of gBGC evolution, while stressing the need for gBGC-aware models in population genetics and phylogenetics.