RT Journal Article
SR Electronic
T1 Association of Peripheral Blood Pressure with Grey Matter Volume in 19- to 40-Year-Old Adults
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 239160
DO 10.1101/239160
A1 H. Lina Schaare
A1 Shahrzad Kharabian Masouleh
A1 Frauke Beyer
A1 Deniz Kumral
A1 Marie Uhlig
A1 Janis D. Reinelt
A1 Andrea M.F. Reiter
A1 Leonie Lampe
A1 Anahit Babayan
A1 Miray Erbey
A1 Josefin Roebbig
A1 Matthias L. Schroeter
A1 Hadas Okon-Singer
A1 Karsten Müller
A1 Natacha Mendes
A1 Daniel S. Margulies
A1 A. Veronica Witte
A1 Michael Gaebler
A1 Arno Villringer
YR 2018
UL http://biorxiv.org/content/early/2018/09/10/239160.abstract
AB Objective To test whether elevated blood pressure (BP) relates to grey matter volume (GMV) changes in young adults who had not previously been diagnosed as hypertensive (systolic BP (SBP)/diastolic BP (DBP)≥140/90 mmHg).Methods We associated BP with GMV from structural 3 Tesla T1-weighted MRI of 423 healthy adults between 19-40 years (mean age=27.7±5.3 years, 177 women, SBP/DBP=123.2/73.4±12.2/8.5 mmHg). Data originated from four previously unpublished cross-sectional studies conducted in Leipzig, Germany. We performed voxel-based morphometry on each study separately and combined results in image-based meta-analyses (IBMA) to assess cumulative effects across studies. Resting BP was assigned to one of four categories: (1) SBP<120 and DBP<80 mmHg, (2) SBP 120-129 or DBP 80-84 mmHg, (3) SBP 130-139 or DBP 85-89 mmHg, (4) SBP≥140 or DBP≥90 mmHg.Results IBMA yielded: (a) lower regional GMV was correlated with higher peripheral BP; (b) lower GMV with higher BP when comparing individuals in sub-hypertensive categories 3 and 2, respectively, to those in category 1; (c) lower BP-related GMV was found in regions including hippocampus, amygdala, thalamus, frontal and parietal structures (e.g. precuneus).Conclusions BP≥120/80 mmHg was associated with lower GMV in regions that have previously been related to GM decline in older individuals with manifest hypertension. Our study shows that BP-associated GM alterations emerge continuously across the range of BP and earlier in adulthood than previously assumed. This suggests that treating hypertension or maintaining lower BP in early adulthood might be essential for preventing the pathophysiological cascade of asymptomatic cerebrovascular disease to symptomatic end-organ damage, such as stroke or dementia.Author contributionsStudy concept and design: Schaare, Villringer.Statistical analysis: Schaare.Acquisition or interpretation of data: All authors.Drafting of the manuscript: Schaare, Villringer.Critical revision of the manuscript: All authors.We thank all volunteers for their participation in any of the studies. Furthermore, we thank all researchers, technicians and students who planned, collected, entered and curated data used in this manuscript.