RT Journal Article
SR Electronic
T1 New Drosophila long-term memory genes revealed by assessing computational function prediction methods
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 414565
DO 10.1101/414565
A1 Kacsoh, Balint Z.
A1 Barton, Stephen
A1 Jiang, Yuxiang
A1 Zhou, Naihui
A1 Mooney, Sean D.
A1 Friedberg, Iddo
A1 Radivojac, Predrag
A1 Greene, Casey S.
A1 Bosco, Giovanni
YR 2018
UL http://biorxiv.org/content/early/2018/09/11/414565.abstract
AB A major bottleneck to our understanding of the genetic and molecular foundation of life lies in the ability to assign function to a gene and, subsequently, a protein. Traditional molecular and genetic experiments can provide the most reliable forms of identification, but are generally low-throughput, making such discovery and assignment a daunting task. The bottleneck has led to an increasing role for computational approaches. The Critical Assessment of Functional Annotation (CAFA) effort seeks to measure the performance of computational methods. In CAFA3 we performed selected screens, including an effort focused on long-term memory. We used homology and previous CAFA predictions to identify 29 key Drosophila genes, which we tested via a long-term memory screen. We identify 11 novel genes that are involved in long-term memory formation and show a high level of connectivity with previously identified learning and memory genes. Our study provides first higher-order behavioral assay and organism screen used for CAFA assessments and revealed previously uncharacterized roles of multiple genes as possible regulators of neuronal plasticity at the boundary of information acquisition and memory formation.