PT  - JOURNAL ARTICLE
AU  - Lukas B. Krone
AU  - Tomoko Yamagata
AU  - Cristina Blanco-Duque
AU  - Mathilde C. C. Guillaumin
AU  - Martin C. Kahn
AU  - Colin J. Akerman
AU  - Anna Hoerder-Suabedissen
AU  - Zoltán Molnár
AU  - Vladyslav V. Vyazovskiy
TI  - A role for the cortex in sleep-wake regulation
AID  - 10.1101/2020.03.17.996090
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.03.17.996090
4099  - http://biorxiv.org/content/early/2020/04/18/2020.03.17.996090.short
4100  - http://biorxiv.org/content/early/2020/04/18/2020.03.17.996090.full
AB  - The cortex and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global control of vigilance states. Here we silenced a subset of cortical layer 5 pyramidal and dentate gyrus granule cells in mice using a cell-specific ablation of the key t-SNARE protein SNAP25. We found a marked increase in wakefulness accompanied by a reduced rebound of EEG slow-wave activity after sleep deprivation. Our data illustrates an important role for the cortex in both global state control and sleep homeostasis.Competing Interest StatementThe authors have declared no competing interest.