RT Journal Article
SR Electronic
T1 Ancestral admixture and structural mutation define global biodiversity in fission yeast
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 415091
DO 10.1101/415091
A1 Sergio Tusso
A1 Bart P.S. Nieuwenhuis
A1 Fritz J. Sedlazeck
A1 John W. Davey
A1 Daniel Jeffares
A1 Jochen B. W. Wolf
YR 2018
UL http://biorxiv.org/content/early/2018/09/12/415091.abstract
AB Mutation and recombination are key evolutionary processes governing phenotypic variation and reproductive isolation. We here demonstrate that biodiversity within all globally known strains of Schizosaccharomyces pombe arose through admixture between two ancestral lineages. Initial hybridization occurred ∼20 sexual outcrossing generations ago consistent with recent, human-induced migration at the onset of intensified transcontinental trade. Species-wide phenotypic variation was explained near-exclusively by strain-specific arrangements of alternating ancestry components with evidence for transgressive segregation. Reproductive compatibility between strains was likewise predicted by the degree of shared ancestry. Over 800 structural mutations segregating at low frequency had overall little effect on the introgression landscape. This study sheds new light on the population history of S. pombe and illustrates the importance of hybridization as a creative force in generating biodiversity.DELdeletionDUPduplicationINSinsertionINVinversion