RT Journal Article SR Electronic T1 A pilot study of assisting IVF by personalized Endo-Gym® exercises JF bioRxiv FD Cold Spring Harbor Laboratory SP 2020.04.19.049379 DO 10.1101/2020.04.19.049379 A1 Katalin Csehek A1 Peter Tompa YR 2020 UL http://biorxiv.org/content/early/2020/04/20/2020.04.19.049379.abstract AB Assisted reproductive technologies (ARTs), especially in vitro fertilization (IVF) have revolutionized human reproduction technology, helping millions of subfertile couples to conceive and deliver a baby. IVF, however, is not an easy procedure, as treatment cycles incur heavy financial, physical and psychological burden, yet they result in live birth less than once in four attempts. Based on our experience with 251 women, many in their 40s, here we suggest that Endo-Gym® method (for endocrine gymnastics), a combination of personalized physical exercises, fertility-optimizing diet and personal coaching, can significantly increase IVF success, probably by both reducing distress caused by repeated cycles and alleviating fertility-affecting problems, such as polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). The program can also relieve other gynecological conditions, such as irregular or painful period, pelvic organ prolapse (POP) and incontinence, and is also often chosen by women as their regular fitness regime for general wellbeing. We provide detailed statistics of success in various conditions and suggest that distinct elements of Endo-Gym® cooperate to exert positive physiological and psychological effects that help re-establish sexual hormone balance and boost reproductive fitness. We anticipate that further, controlled testing will enable to put the benefits of Endo-Gym® on a rational basis and enable to introduce this approach as a beneficial complement of IVF, and maybe also other branches of ART.Competing Interest StatementThe authors have declared no competing interest.