RT Journal Article
SR Electronic
T1 Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 412718
DO 10.1101/412718
A1 Carinna Hockham
A1 Supachai Ekwattanakit
A1 Samir Bhatt
A1 Bridget S Penman
A1 Sunetra Gupta
A1 Vip Viprakasit
A1 Frédéric B Piel
YR 2018
UL http://biorxiv.org/content/early/2018/09/12/412718.abstract
AB Severe forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart’s hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity and health burden of α-thalassaemia in the region remains limited. We compiled a geodatabase of α-thalassaemia prevalence and genetic diversity surveys and, using geostatistical modelling methods, generated the first continuous maps of α-thalassaemia mutations in Thailand and sub-national estimates of the number of newborns with severe forms in 2020. We also summarised the current evidence-base for α-thalassaemia prevalence and diversity for the region. We estimate that 3,595 (95% credible interval 1,717 – 6,199) newborns will be born with severe α-thalassaemia in Thailand in 2020, which is considerably higher than previous estimates. Accurate, fine-scale epidemiological data are necessary to guide sustainable national and regional health policies for α-thalassaemia control. Our maps and newborn estimates are an important first step towards this aim.Funding This work was supported by European Union’s Seventh Framework Programme (FP7//2007-2013)/European Research Council [268904 – DIVERSITY]