PT  - JOURNAL ARTICLE
AU  - Sam Vickery
AU  - William D. Hopkins
AU  - Chet C. Sherwood
AU  - Steven J. Schapiro
AU  - Robert D. Latzman
AU  - Svenja Caspers
AU  - Christian Gaser
AU  - Simon B. Eickhoff
AU  - Robert Dahnke
AU  - Felix Hoffstaedter
TI  - Chimpanzee Brain Morphometry Utilizing Standardized MRI Preprocessing and Macroanatomical Annotations
AID  - 10.1101/2020.04.20.046680
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.04.20.046680
4099  - http://biorxiv.org/content/early/2020/04/20/2020.04.20.046680.short
4100  - http://biorxiv.org/content/early/2020/04/20/2020.04.20.046680.full
AB  - Chimpanzees are among the closest living relatives to humans and, therefore, provide a crucial comparative model for investigating primate brain evolution. In recent years, human brain research has strongly benefited from enhanced computational models and image processing pipelines that could also improve data analyses in animals by using species-specific templates. In this study, we use MRI data from the National Chimpanzee Brain Resource (NCBR) to develop the chimpanzee brain template Juna.Chimp for spatial registration and the novel macro-anatomical brain parcellation Davi130 for standardized whole-brain analysis. Additionally, we introduce a ready-to-use complete image processing pipeline built upon the CAT12 toolbox in SPM12, implementing a standard human image preprocessing framework in chimpanzees. Applying this approach to data from 178 subjects, we find strong evidence for age-related GM atrophy in multiple regions of the chimpanzee brain, as well as, a human-like anterior-posterior pattern of hemispheric asymmetry in medial chimpanzee brain regions.Competing Interest StatementThe authors have declared no competing interest.