RT Journal Article
SR Electronic
T1 Chimpanzee Brain Morphometry Utilizing Standardized MRI Preprocessing and Macroanatomical Annotations
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.04.20.046680
DO 10.1101/2020.04.20.046680
A1 Sam Vickery
A1 William D. Hopkins
A1 Chet C. Sherwood
A1 Steven J. Schapiro
A1 Robert D. Latzman
A1 Svenja Caspers
A1 Christian Gaser
A1 Simon B. Eickhoff
A1 Robert Dahnke
A1 Felix Hoffstaedter
YR 2020
UL http://biorxiv.org/content/early/2020/04/20/2020.04.20.046680.abstract
AB Chimpanzees are among the closest living relatives to humans and, therefore, provide a crucial comparative model for investigating primate brain evolution. In recent years, human brain research has strongly benefited from enhanced computational models and image processing pipelines that could also improve data analyses in animals by using species-specific templates. In this study, we use MRI data from the National Chimpanzee Brain Resource (NCBR) to develop the chimpanzee brain template Juna.Chimp for spatial registration and the novel macro-anatomical brain parcellation Davi130 for standardized whole-brain analysis. Additionally, we introduce a ready-to-use complete image processing pipeline built upon the CAT12 toolbox in SPM12, implementing a standard human image preprocessing framework in chimpanzees. Applying this approach to data from 178 subjects, we find strong evidence for age-related GM atrophy in multiple regions of the chimpanzee brain, as well as, a human-like anterior-posterior pattern of hemispheric asymmetry in medial chimpanzee brain regions.Competing Interest StatementThe authors have declared no competing interest.