PT  - JOURNAL ARTICLE
AU  - Silva, Genivaldo Gueiros Z.
AU  - Dutilh, Bas E.
AU  - Edwards, Robert A.
TI  - FOCUS2: agile and sensitive classification of metagenomics data using a reduced database
AID  - 10.1101/046425
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 046425
4099  - http://biorxiv.org/content/early/2016/03/31/046425.short
4100  - http://biorxiv.org/content/early/2016/03/31/046425.full
AB  - Summary Metagenomics approaches rely on identifying the presence of organisms in the microbial community from a set of unknown DNA sequences. Sequence classification has valuable applications in multiple important areas of medical and environmental research. Here we introduce FOCUS2, an update of the previously published computational method FOCUS. FOCUS2 was tested with 10 simulated and 543 real metagenomes demonstrating that the program is more sensitive, faster, and more computationally efficient than existing methods.Availability The Python implementation is freely available at https://edwards.sdsu.edu/FOCUS2.Supplementary information available at Bioinformatics online.