TY - JOUR T1 - Multiple modulation synthesis with high spatial resolution for noninvasive deep neurostimulation JF - bioRxiv DO - 10.1101/416057 SP - 416057 AU - Qiaoqin Xiao AU - Xiaozheng Lai AU - Hao Chen Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/09/14/416057.abstract N2 - Noninvasive neurostimulation plays a pivotal role in direct control of neural circuit and modulating neuronal function. However, it is difficult to balance both spatial focality and depth of penetration in stimulating deep neurons. Here, we designed time-division, frequency & polarity modulation synthesis (TMFPMS) for stimulating deep neurons noninvasively with low-frequency envelope. We demonstrated its spatial resolution: mm-level via computational simulation including finite element analysis and Hodgkin-Huxley action potential model. Taken together, the results of this study indicate that TMFPMS neurostimulation with high spatial resolution is steerable and may replace traditional implanted electrode. ER -