PT  - JOURNAL ARTICLE
AU  - Qiaoqin Xiao
AU  - Xiaozheng Lai
AU  - Hao Chen
TI  - Multiple modulation synthesis with high spatial resolution for noninvasive deep neurostimulation
AID  - 10.1101/416057
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 416057
4099  - http://biorxiv.org/content/early/2018/09/14/416057.short
4100  - http://biorxiv.org/content/early/2018/09/14/416057.full
AB  - Noninvasive neurostimulation plays a pivotal role in direct control of neural circuit and modulating neuronal function. However, it is difficult to balance both spatial focality and depth of penetration in stimulating deep neurons. Here, we designed time-division, frequency & polarity modulation synthesis (TMFPMS) for stimulating deep neurons noninvasively with low-frequency envelope. We demonstrated its spatial resolution: mm-level via computational simulation including finite element analysis and Hodgkin-Huxley action potential model. Taken together, the results of this study indicate that TMFPMS neurostimulation with high spatial resolution is steerable and may replace traditional implanted electrode.