RT Journal Article
SR Electronic
T1 A flexible target-specific anti-infection therapeutic platform that can be applied to different microbial species
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.04.20.049791
DO 10.1101/2020.04.20.049791
A1 Makoto Mitsunaga
A1 Kimihiro Ito
A1 Takashi Nishimura
A1 Hironori Miyata
A1 Yoshimitsu Mizunoe
A1 Hisataka Kobayashi
A1 Tadayuki Iwase
YR 2020
UL http://biorxiv.org/content/early/2020/04/23/2020.04.20.049791.abstract
AB The emergence of new microbial pathogens, including drug-resistant strains, complicates treatment, thereby threatening global health. We demonstrated a photoimmuno-antimicrobial strategy (PIAS) that eliminated antibody-targets using a photo-activated anti-pathogen antibody generating mechanical stress that damaged the target’s binding sites. PIAS is effective against many pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), the fungal pathogen Candida albicans, and viral particles irrespective of their species or drug-resistance status. Animal experiments demonstrated that PIAS saved mice from fatal infections; microbiome and histochemical analyses indicated no apparent effect on normal host microflora and tissues in PIAS-treated mice. Resistance to PIAS was not observed during the eight years of this study. As a new type of anti-infection therapy, PIAS may contribute to advances in anti-infection strategies.Competing Interest StatementThe authors have declared no competing interest.