%0 Journal Article %A James A. Winkelmann %A Graham Spicer %A Aya Eid %A Luay M. Almassalha %A The-Quyen Nyguen %A Vadim Backman %T Spectral Contrast Optical Coherence Tomography Angiography Enables Single-Scan Vessel Imaging %D 2018 %R 10.1101/406652 %J bioRxiv %P 406652 %X Optical Coherence Tomography angiography relies on motion for contrast and requires at least two data acquisitions per point-wise scanning location. We present a method termed Spectral Contrast Optical Coherence Tomography Angiography using visible light which relies on the spectral signatures of blood to obtain angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method enabling lymphatic, blood, and tissue discrimination. %U https://www.biorxiv.org/content/biorxiv/early/2018/09/16/406652.full.pdf