TY - JOUR T1 - Spectral Contrast Optical Coherence Tomography Angiography Enables Single-Scan Vessel Imaging JF - bioRxiv DO - 10.1101/406652 SP - 406652 AU - James A. Winkelmann AU - Graham Spicer AU - Aya Eid AU - Luay M. Almassalha AU - The-Quyen Nyguen AU - Vadim Backman Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/09/16/406652.abstract N2 - Optical Coherence Tomography angiography relies on motion for contrast and requires at least two data acquisitions per point-wise scanning location. We present a method termed Spectral Contrast Optical Coherence Tomography Angiography using visible light which relies on the spectral signatures of blood to obtain angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method enabling lymphatic, blood, and tissue discrimination. ER -