RT Journal Article
SR Electronic
T1 Circuits for integrating learnt and innate valences in the fly brain
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.04.23.058339
DO 10.1101/2020.04.23.058339
A1 Claire Eschbach
A1 Akira Fushiki
A1 Michael Winding
A1 Bruno Afonso
A1 Ingrid V Andrade
A1 Benjamin T Cocanougher
A1 Katharina Eichler
A1 Ruben Gepner
A1 Guangwei Si
A1 Javier Valdes-Aleman
A1 Marc Gershow
A1 Gregory SXE Jefferis
A1 James W Truman
A1 Richard D Fetter
A1 Aravinthan Samuel
A1 Albert Cardona
A1 Marta Zlatic
YR 2020
UL http://biorxiv.org/content/early/2020/04/24/2020.04.23.058339.abstract
AB Animal behavior is shaped both by evolution and by individual experience. In many species parallel brain pathways are thought to encode innate and learnt behavior drives and as a result may link the same sensory cue to different actions if innate and learnt drives are in opposition. How these opposing drives are integrated into a single coherent action is not well understood. In insects, the Mushroom Body Output Neurons (MBONs) and the Lateral Horn Neurons (LHNs) are thought to provide the learnt and innate drives, respectively. However their patterns of convergence and the mechanisms by which their outputs are used to select actions are not well understood. We used electron microscopy reconstruction to comprehensively map the downstream targets of all MBONs in Drosophila larva and characterise their patterns of convergence with LHNs. We discovered convergence neurons that receive direct input from MBONs and LHNs and compare opposite behaviour drives. Functional imaging and optogenetic manipulation suggest these convergence neurons compute the overall predicted value of approaching or avoiding an odor and mediate action selection. Our study describes the circuit mechanisms allowing integration of opposing drives from parallel olfactory pathways.Competing Interest StatementThe authors have declared no competing interest.