PT  - JOURNAL ARTICLE
AU  - Daniel S. Kluger
AU  - Joachim Gross
TI  - Respiration modulates oscillatory neural network activity at rest
AID  - 10.1101/2020.04.23.057216
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.04.23.057216
4099  - http://biorxiv.org/content/early/2020/04/25/2020.04.23.057216.short
4100  - http://biorxiv.org/content/early/2020/04/25/2020.04.23.057216.full
AB  - Despite recent advances in understanding how respiration affects neural signalling to influence perception, cognition, and behaviour, it is yet unclear to what extent breathing modulates brain oscillations at rest. We acquired respiration and resting state magnetoencephalography (MEG) data from human participants to investigate if, where, and how respiration cyclically modulates oscillatory amplitudes (2 - 150 Hz). Using measures of phase-amplitude coupling, we show respiration-modulated brain oscillations (RMBOs) across all major frequency bands. Sources of these modulations spanned a widespread network of cortical and subcortical brain areas which formed clusters with distinct spectro-temporal modulation profiles. Globally, gamma modulation increased with distance to the head centre, whereas delta and theta modulation decreased with height in the sagittal plane. Overall, we provide the first comprehensive mapping of RMBOs across the entire brain, highlighting respiration-brain coupling as a fundamental mechanism to shape neural processing within canonical resting-state and respiratory control networks.Competing Interest StatementThe authors have declared no competing interest.