RT Journal Article
SR Electronic
T1 Identification and characterization of the hypoxia response regulatory elements in the accessible genome
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.04.24.059105
DO 10.1101/2020.04.24.059105
A1 Xi Lu
A1 Xingqi Chen
YR 2020
UL http://biorxiv.org/content/early/2020/04/25/2020.04.24.059105.abstract
AB Hypoxia is commonly observed in the solid tumor and contributes to the drug resistance in cancer therapy. Deciphering the epigenetic feature under the hypoxia condition in the solid tumor is critical for us to understand the tumorigenesis and design the precision therapy. Using the time series of ATAC-seq data under the hypoxia treatment from the epithelia cells, we identified the hypoxia response regulatory elements (HRREs) in the accessible genome. We found that these different HRREs have unique genomic features and are enriched with different transcriptional factors (TFs). Our study provides insights into the chromatin structure response to the hypoxia treatment and identifies useful genomic features for a better understanding of the hypoxia biology in the solid tumor.Competing Interest StatementThe authors have declared no competing interest.