PT - JOURNAL ARTICLE AU - Mirdita, Milot AU - Steinegger, Martin AU - Söding, Johannes TI - MMseqs2 desktop and local web server app for fast, interactive sequence searches AID - 10.1101/419895 DP - 2018 Jan 01 TA - bioRxiv PG - 419895 4099 - http://biorxiv.org/content/early/2018/09/18/419895.short 4100 - http://biorxiv.org/content/early/2018/09/18/419895.full AB - The MMseqs2 desktop and web server app facilitates interactive sequence searches through custom protein sequence and profile databases on personal workstations. By eliminating MMseqs2’s runtime overhead, we reduced response times to a few seconds at sensitivities close to BLAST.Availability and implementation The app is easy to install for non-experts. Source code, prebuilt desktop app packages for Windows, macOS and Linux, Docker images for the web server application, and a demo web server are available at https://search.mmseqs.com.Contact martin.steinegger{at}mpibpc.mpg.de or soeding{at}mpibpc.mpg.de