PT - JOURNAL ARTICLE AU - McKay, Paul F. AU - Hu, Kai AU - Blakney, Anna K. AU - Samnuan, Karnyart AU - Bouton, Clément R. AU - Rogers, Paul AU - Polra, Krunal AU - Lin, Paulo J.C. AU - Barbosa, Christopher AU - Tam, Ying AU - Shattock, Robin J. TI - Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients AID - 10.1101/2020.04.22.055608 DP - 2020 Jan 01 TA - bioRxiv PG - 2020.04.22.055608 4099 - http://biorxiv.org/content/early/2020/04/25/2020.04.22.055608.short 4100 - http://biorxiv.org/content/early/2020/04/25/2020.04.22.055608.full AB - The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine and demonstrate induction of robust neutralization of a pseudo-virus, proportional to quantity of specific IgG and of higher quantities than recovered COVID-19 patients. These data provide insight into the vaccine design and evaluation of immunogenicity to enable rapid translation to the clinic.Competing Interest StatementThe authors have declared no competing interest.