PT - JOURNAL ARTICLE AU - Mehdi Azimipour AU - Justin V. Migacz AU - Robert J. Zawadzki AU - John S. Werner AU - Ravi S. Jonnal TI - Functional retinal imaging using adaptive optics swept-source OCT at 1.6MHz AID - 10.1101/420240 DP - 2018 Jan 01 TA - bioRxiv PG - 420240 4099 - http://biorxiv.org/content/early/2018/09/18/420240.short 4100 - http://biorxiv.org/content/early/2018/09/18/420240.full AB - Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A-scans at 1.64MHz with a center wavelength of 1063nm, and an AO subsystem providing diffraction-limited imaging. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus intensity, as well as other morphological changes in the outer segment and retinal pigment epithelium.