PT - JOURNAL ARTICLE AU - Wei Zhang AU - Longlong Wang AU - Ke Liu AU - Xiaofeng Wei AU - Kai Yang AU - Wensi Du AU - Shiyu Wang AU - Nannan Guo AU - Chuanchuan Ma AU - Lihua Luo AU - Jinghua Wu AU - Liya Lin AU - Fan Yang AU - Fei Gao AU - Xie Wang AU - Tao Li AU - Ruifang Zhang AU - Nitin K. Saksena AU - Huanming Yang AU - Jian Wang AU - Lin Fang AU - Yong Hou AU - Xun Xu AU - Xiao Liu TI - PIRD: Pan immune repertoire database AID - 10.1101/399493 DP - 2018 Jan 01 TA - bioRxiv PG - 399493 4099 - http://biorxiv.org/content/early/2018/09/20/399493.short 4100 - http://biorxiv.org/content/early/2018/09/20/399493.full AB - The adaptive immunity is highly specific and mainly comprised of humoral immunity, mediated by antibodies produced by B lymphocytes, and cell-mediated immunity, mediated by T lymphocytes. The huge variety of T and B cell receptor (TCR and BCR) repertoire is vital in directly binding to various auto-and-external antigens. This repertoire is a critical resource for a clear understanding of the immune response and highlights its utility in clinical applications. In recent years, even thousands of samples have been captured for studying TCR and BCR repertoire using sequencing platforms, very few databases have been constructed to store these sequences. To resolve this issue, we have developed a database Pan immune repertoire database (PIRD), located the infrastructure of in China National GeneBank (CNGB) to collect and store the annotated TCR and BCR sequencing data, including Homo sapiens and other species. Except for the primary data storage, PIRD also provides the data visualization function in addition to the interactive online analysis. Additionally, a manually curated database of T- and B-cell receptors targeting known antigens (TBAdb) are also deposited in PIRD. The database is displayed in both English and Chinese on the PIRD website. PIRD can be accessed at https://db.cngb.org/pird/.