PT  - JOURNAL ARTICLE
AU  - Y Liu
AU  - SS McAfee
AU  - RV Sillitoe
AU  - DH Heck
TI  - Cerebellar modulation of prefrontal-hippocampal gamma coherence during spatial working memory decisions
AID  - 10.1101/2020.03.16.994541
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.03.16.994541
4099  - http://biorxiv.org/content/early/2020/04/30/2020.03.16.994541.short
4100  - http://biorxiv.org/content/early/2020/04/30/2020.03.16.994541.full
AB  - The medial prefrontal cortex (mPFC) and dorsal hippocampal CA1 region (dCA1) in rodents show increased coherence of neuronal oscillations during decisions in learned spatial working memory (SWM) tasks and the coherence changes reflect decision outcome. However, how coherence is controlled is unknown. We found in mice that decision related gamma coherence modulation between the mPFC and dCA1 and normal SWM performance required an intact cerebellum. Optogenetic activation of the cerebellar lobulus simplex impaired decision-related mPFC-dCA1 coherence modulation and SWM performance. Our findings reveal a role for the cerebellum in the task-specific modulation of coherence between cerebral cortical areas as possible mechanism of cerebellar cognitive function.Competing Interest StatementThe authors have declared no competing interest.