RT Journal Article
SR Electronic
T1 Endoglycan plays a role in axon guidance and neuronal migration by negatively regulating cell-cell adhesion
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 425207
DO 10.1101/425207
A1 Thomas Baeriswyl
A1 Georgia Tsapara
A1 Vera Niederkofler
A1 Jeannine A. Frei
A1 Nicole H. Wilson
A1 Matthias Gesemann
A1 Esther T. Stoeckli
YR 2018
UL http://biorxiv.org/content/early/2018/09/24/425207.abstract
AB Cell migration and axon guidance are important steps in the formation of neural circuits. Both steps depend on the interactions between cell surface receptors and molecules on cells along the pathway. In addition to cell-cell adhesion, these molecular interactions provide guidance information. The fine-tuning of cell-cell adhesion is as an important aspect of cell migration, axon guidance, and synapse formation. Here, we show that Endoglycan, a sialomucin, plays a role in axon guidance and cell migration in the central nervous system. In the absence of Endoglycan, commissural axons failed to cross the midline of the spinal cord. In the developing cerebellum, a lack of Endoglycan prevented migration of Purkinje cells and resulted in a stunted growth of the cerebellar lobes. Taken together, these results support the hypothesis that Endoglycan acts as a negative regulator of cell-cell adhesion in both commissural axon guidance and Purkinje cell migration.