@article {Osawa2020.05.04.076612, author = {Motoki Osawa and Yasuhiro Ueno and Noriaki Ikeda and Kazuya Ikematsu and Takuma Yamamoto and Wataru Irie and Shuji Kozawa and Hirokazu Kotani and Hideki Hamayasu and Takehiko Murase and Keita Shingu and Marie Sugimoto and Ryoko Nagao and Yu Kakimoto}, title = {Circumstances and factors of sleep-related sudden infancy deaths in Japan}, elocation-id = {2020.05.04.076612}, year = {2020}, doi = {10.1101/2020.05.04.076612}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Background Sudden unexpected death in infancy (SUDI) comprises both natural and unnatural causes of death. However, a few epidemiological surveys have investigated SUDI in Japan.Objective This retrospective study was conducted to investigate the recent trends of circumstances and risk factors of sleep-related SUDI cases.Methods Forensic pathology sections from eight universities participated in the selection of subjects from 2013 to 2018. Data obtained from the checklist form were analyzed based on information at postmortem.Results There were 259 SUDI cases consisting of 145 male infants and 114 female infants with a mean birth weight of 2888 {\textpm} 553 and 2750 {\textpm} 370 g, respectively. Deaths most frequently occurred among infants at 1 month of age (18\%). According to population-based analyses, the odds ratio (95\% confidence interval) of mother{\textquoteright}s age <=19 years was 11.1 (6.9{\textendash}17.7) compared with ages 30{\textendash}39. The odds ratio for the fourth- and later born infants was 5.2 (3.4{\textendash}7.9) compared with the frequency of first-born infants. The most frequent time of day for discovery was between 7 and 8 o{\textquoteright}clock. Co-sleeping was recorded for 61\%, and the prone position was found for 40\% of cases at discovery. Mother{\textquoteright}s smoking habit exhibited an adds ratio of 4.5 (2.9{\textendash}5.8).Conclusion This study confirmed the trends that have been observed for sudden infant death syndrome; particularly, very high odds ratios were evident for teenage mothers and later birth order in comparison with those in other developed countries. The child of a young mother tended to die within 2 months of age. To our knowledge, this is the first report of an extensive survey of sleep-related SUDI in Japan.}, URL = {https://www.biorxiv.org/content/early/2020/05/04/2020.05.04.076612}, eprint = {https://www.biorxiv.org/content/early/2020/05/04/2020.05.04.076612.full.pdf}, journal = {bioRxiv} }